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An increase in expression of the ob gene in obese subjects has since been reported by other investigators. , Joanna P. , Madhur K. D. The administration of recombinant leptin causes weight loss in these mice. , Mark L. D. Figure 3 Effect of Weight Loss on Serum Leptin Concentrations and Expression of the ob Gene in Seven Obese Subjects, Expressed as a Percentage of the Initial Value. 2-4 We have reported the complete coding sequence of human ob complementary DNA (cDNA), 5 a finding recently confirmed by others. Original Article Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans Robert V. S. , Thomas W. Usain Bolt speaks with silver medalist Tyson Gay of the United States at London 2012. The scene outside the Cook Out following the shooting. The ob messenger RNA (mRNA) content of adipocytes was determined in 27 normal-weight and 27 obese subjects. The measurements were repeated in seven obese subjects after weight loss and during maintenance of the lower weight. Stephens, Ph. She was taken to hospital for treatment but died from her injuries just before 5am today. Media in This Article Figure 1 The Relation between the Percentage of Body Fat and the Serum Leptin Concentration in 136 Normal-Weight and 139 Obese Subjects. In eight normal-weight and eight obese subjects the amount of ob messenger RNA (mRNA) in adipocytes was correlated with body weight. D.
Sinha, Ph. , Aidas Kriauciunas, Ph. , Mark R. Heiman, Ph. D. 6 We did not detect any mutations in the gene in five obese subjects. Abstract Background Leptin, the product of the ob gene, is a hormone secreted by adipocytes. Police revealed they have two people of interest in the case they are questioning because their car matched the description of of the Charger involved in the shootout. Conclusions Serum leptin concentrations are correlated with the percentage of body fat, suggesting that most obese persons are insensitive to endogenous leptin production. Witnesses reported gunfire between exchanged between a grey Dodge Charger and a dark-colored sports car with tinted windows, police said. Considine, Ph. D. Article Activity 2437 articles have cited this article Article The ob gene is an adipocyte-specific gene that encodes leptin, a protein that regulates body weight. Animals with mutations in the ob gene are obese and lose weight when given leptin, but little is known about the physiologic actions of leptin in humans. Cops responded to reports of shots being fired at the Cook Out restaurant just before 4am. Comments By Sam Adams 16:16, 16 OCT 2016 Updated 22:48, 16 OCT 2016 News Video Loading Video Unavailable Click to play Tap to play The video will start in 8 Cancel Play now Watch this video again Video will play in. Nyce, M. 1 In mice, mutations in the ob gene that result in a lack of circulating leptin cause obesity. Trinity Gay, also a talented runner, is believed to have been hit while eating at a Cook Out branch in Lexington, Kentucky.
